diff --git a/internal/constants/constants.go b/internal/constants/constants.go
index 22e2eea..e19b3b7 100644
--- a/internal/constants/constants.go
+++ b/internal/constants/constants.go
@@ -49,6 +49,7 @@ const (
 	ProcDomainDestroyFlags       = 234
 	ProcConnectListAllDomains    = 273
 	ProcMigratePerformParams     = 305
+	ProcDomainDefineXMLFlags     = 350
 )
 
 // qemu procedure identifiers
diff --git a/libvirt.go b/libvirt.go
index 795e776..19996ef 100644
--- a/libvirt.go
+++ b/libvirt.go
@@ -159,6 +159,14 @@ const (
 	UndefineFlagNVRAM
 )
 
+// DomainDefineXMLFlags specifies options available when defining a domain.
+type DomainDefineXMLFlags uint32
+
+const (
+	// DefineValidate validates the XML document against schema
+	DefineValidate DomainDefineXMLFlags = 1
+)
+
 // DestroyFlags specifies options available when destroying a domain.
 type DestroyFlags uint32
 
@@ -641,6 +649,34 @@ func (l *Libvirt) XML(dom string, flags DomainXMLFlags) ([]byte, error) {
 	return []byte(s), nil
 }
 
+// DefineXML defines a domain, but does not start it.
+func (l *Libvirt) DefineXML(x []byte, flags DomainDefineXMLFlags) error {
+	payload := struct {
+		Domain []byte
+		Flags  DomainDefineXMLFlags
+	}{
+		Domain: x,
+		Flags:  flags,
+	}
+
+	buf, err := encode(&payload)
+	if err != nil {
+		return err
+	}
+
+	resp, err := l.request(constants.ProcDomainDefineXMLFlags, constants.ProgramRemote, &buf)
+	if err != nil {
+		return err
+	}
+
+	r := <-resp
+	if r.Status != StatusOK {
+		return decodeError(r.Payload)
+	}
+
+	return nil
+}
+
 // Version returns the version of the libvirt daemon.
 func (l *Libvirt) Version() (string, error) {
 	resp, err := l.request(constants.ProcConnectGetLibVersion, constants.ProgramRemote, nil)
diff --git a/libvirt_test.go b/libvirt_test.go
index 871bbab..d734308 100644
--- a/libvirt_test.go
+++ b/libvirt_test.go
@@ -254,3 +254,14 @@ func TestVersion(t *testing.T) {
 		t.Errorf("expected version %q, got %q", expected, version)
 	}
 }
+
+func TestDefineXML(t *testing.T) {
+	conn := libvirttest.New()
+	l := New(conn)
+
+	var flags DomainDefineXMLFlags
+	var buf []byte
+	if err := l.DefineXML(buf, flags); err != nil {
+		t.Fatalf("unexpected define error: %v", err)
+	}
+}
diff --git a/libvirttest/libvirt.go b/libvirttest/libvirt.go
index 1528960..192a726 100644
--- a/libvirttest/libvirt.go
+++ b/libvirttest/libvirt.go
@@ -248,6 +248,22 @@ var testVersionReply = []byte{
 	0x00, 0x00, 0x00, 0x00, 0x00, 0x0f, 0x4d, 0xfc, // version (1003004)
 }
 
+var testDefineXML = []byte{
+	0x00, 0x00, 0x00, 0x38, // length
+	0x20, 0x00, 0x80, 0x86, // program
+	0x00, 0x00, 0x00, 0x01, // version
+	0x00, 0x00, 0x01, 0x5e, // procedure
+	0x00, 0x00, 0x00, 0x01, // type
+	0x00, 0x00, 0x00, 0x00, // serial
+	0x00, 0x00, 0x00, 0x00, // status
+	0x00, 0x00, 0x00, 0x04, // dom
+	0x74, 0x65, 0x73, 0x74, // name
+	// uuid
+	0xaf, 0xc2, 0xef, 0x71, 0x66, 0xe0, 0x45, 0xa7,
+	0xa5, 0xec, 0xd8, 0xba, 0x1e, 0xa8, 0x17, 0x7d,
+	0xff, 0xff, 0xff, 0xff, // id
+}
+
 // MockLibvirt provides a mock libvirt server for testing.
 type MockLibvirt struct {
 	net.Conn
@@ -315,6 +331,8 @@ func (m *MockLibvirt) handleRemote(procedure uint32, conn net.Conn) {
 		conn.Write(m.reply(testUndefineReply))
 	case constants.ProcDomainDestroyFlags:
 		conn.Write(m.reply(testDestroyReply))
+	case constants.ProcDomainDefineXMLFlags:
+		conn.Write(m.reply(testDefineXML))
 	}
 }